Begum RA1, Chowdhury MIB2, Sharmin N3
Abstract : Background: Because of essential epidemiologic and preventive actions, autopsies on COVID-19 dead patients have several constraints. One area of ongoing neglect and missed possibilities for COVID-19 research is correctly characterizing the pathological characteristics of COVID-19 and determining the underlying cause(s) of COVID-19 death in hospitals. Objective: The goal of this study was to identify the pathognomonic parameters linked with COVID-19 mortality in 100 postmortem completed body autopsies. Materials and Methods: An observational descriptive analysis of reports from 100 COVID-19 inpatient fatalities whose proximate cause of death was SARS-CoV-2 infection (positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction) (RT-PCR). The hospital fatalities happened in the COVID-19 isolation wards of the different government medical college hospital in Bangladesh between March 2020 and March 2021. The autopsy was chosen based on the physi cian's request. Results: Diffuse alveolar damage was detected in (45%), while emboli were identified in 36%. pneumonia was 29%, granular kidneys were 18%, disseminated thrombi was 12%, and deep venous thrombosis was 8%. The primary gross pathology and microscopic autopsy findings, as well as the cause(s) of death were pulmonary thromboembolism (46.0%), diffuse alveolar damage (DAD) (33.0%), and COVID-19 pneumonia (21.0%). Conclusion: COVID-19 fatalities in hospitalized decedents exhibit a wide range of gross anatomical and histological abnormalities. The primary gross pathology and microscopic autopsy findings, as well as the cause(s) of death Pulmonary thromboembolism, Diffuse Alveolar Damage (DAD), and COVID-19 pneumonia were the leading reasons of mortality. Keywords: Pathognomonic factors, COVID-19, postmortem, autopsies.
