Mishu FA1, Akter H2, Ahsan SB3, Khatun A4, Ferdous S5
Background: Diabetic retinopathy is one of the most sights threatening microvascular complication with increasing prevalence of diabetes mellitus throughout the world. It can go undetected & not even noticed until irreversible damage. Hyperhomocysteinemia is related to retinal vasculopathy seen in diabetic retinopathy. The aim of this study is to explore the association of serum homocysteine level with the glycemic status of diabetes & diabetic retinopathy to limit the development & progression of retinopathy from diabetes mellitus. Materials and method: This cross-sectional study was conducted in the Department of Biochemistry and Molecular Biology, BIRDEM Academy over a period of six months. According to inclusion criteria, after taking informed written consent from 90 respondents and their caregivers, a structured questionnaire was filled up for each subject. The total study population were divided into three groups, as Group I- age & gender matched healthy subjects and Group II- DM without retinopathy and Group III- diagnosed case of diabetic retinopathy. Relevant biochemical parameters such as fasting and 2hours after breakfast blood sugar, HbA1c, serum homocysteine level were meas ured by appropriate method. Statistical analyses were done with the help of SPSS software. Results: In this study, comparison of glycemic parameters (FBS, 2hrs ABF and HbA1c) among three groups were significantly higher in group-III. A positive correlation of HbA1c was found with homocysteine. This study further carried out multiple logistic regression analysis & found significant positive association of diabetic retinopathy with HbA1C and serum homocysteine. Conclusion: This study concluded an idea about diabetic retinopathy and its correlation and association with glycemic status among T2DM patients in Bangladeshi population. This finding may help diabetic patients to achieve effective management strategy to prevent the progression of diabetic retinopathy. Keywords: Diabetic retinopathy; Hyperhomocysteinemia; T2DM patients; HbA1c
