Tahfim T1, Hasan M2, Mannan MB3, Rahman M4, Akter A5, Kabir S6
Background: The global prevalence of chronic kidney disease in diabetic patients is rapidly accelerating due to an increasing number of people living with type 2 diabetes. It has become a significant global problem, increasing human and financial pressures on already overburdened healthcare systems. Materials and method: This cross sectional study was done in the department of Biochemistry and Molecular Biology, BIRDEM Academy from July 2017 to June 2018. Data about socio- demographics and biochemical parameters (fasting serum glucose, HbA1c, serum creatinine and estimated GFR, were measured in 3 groups-healthy individuals, diabetic patients without CKD and diabetic patientswith CKD (63 subjects in each group) by appropriate method. The data was then analyzed and expressed in tables and charts with SPSS version 22. Results: Male and female were 62.4% and 37.6% respectively. Mean HbA1c in healthy people and diabetic patient without CKD and diabetic patient with CKD were 4.70±0.47, 7.81±1.83 and 9.00±2.51% respectively. HbA1c was significantly higher in diabetic patient with CKD than other two groups (p<0.001).We found a negative correlation of HbA1C with eGFR(p<0.001). Conclusion: This study concluded that increased HbA1c level is associated with development of CKD in type 2 diabetic patients. Keywords: Diabetes Mellitus, Chronic Kidney Disease, HbA1c, eGFR Introduction: The incidence of diabetes is increasing worldwide, with subsequent increase in the incidence of diabetic nephropathy1. The International Diabetes Federation (IDF) has estimated that 463 million adults live with diabetes worldwide in 2019, with a projected increase
