Khandaker M1, Refat MNH2, Ferdouse F3, Shormin M4, Ferdous S5, Hassan M6
Background: Urinary tract infection (UTI) causes considerable morbidity and mortality worldwide, predominant ly in developing countries like Bangladesh. The empirical selection of antibiotics for the treatment of urinary tract infections frequently deviates from the drug susceptibility of the pathogens. Objective: This study aimed to explore the antimicrobial susceptibility pattern of uropathogens. Materials and methods: Mid stream urine samples from 1502 patients of suspected UTI were collected, cultured and subjected to appropriate biochemical tests. Samples were collected and tested at the microbiology laboratory of Shaheed Monsur Ali Medical College, Uttara, Dhaka from August 2022 to July 2023. The antimicrobial sensitivity test was carried out by disc diffusion technique using Muller- Hinton agar. Urine samples were cultured positive with a colony count equal or more than 105/ml. Results: Overall males to female ratio was 1:1.44. The predominant organisms isolated were Escherichia coli (78.5%) followed by Pseudomonas Spp. (6.2%), Klebsiella spp. (6.2%), Staphylococcus aureus (5.3%) and Enterococcus (4.7%). The majority of uropathogen is isolated were sensitive to imipenem (94%) followed by meropenom(85%), nitrofurantoin(86%) whereas, high level resistance was seen to azithromycin, ceftriaxone,ce fixime followed by ciprofloxacin, cefuroxime in decreasing order of frequency. Conclusion: Various microorgan isms are responsible for UTI explored in this study. Though antimicrobial resistance has already emerged against many antibiotics this study findings will guide clinicians to initiate the empiric antibiotic therapy for UTI. Keywords: Antimicrobial Susceptibility, Uropathogens, Tertiary Hospital, Bangladesh
